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Background : Presence of thalassaemia is considered high risk in pregnancy. The present study find out the role of antenatal and intrapartum care to improve the outcome of pregnancy in thalassaemia. Materials and Method : The prospective longitudinal study was carried out on 25 patients. CBC, LFT, Ferritin, Hb electrophoresis, serial USG was done. Chorionic villous sampling was offered to thalassaemic women to decrease the number of babies born with Thalassaemia. Furthermore, management and treatment options provided to mother to overcome the incidence of maternal and neonatal complications during current pregnancy. Results : 44% of thalassaemic pregnant women had HbE ? thalassaemia, 8% ? thalassaemia major and others had thalassaemia carriers, while only 20% of their partners showed ? thalassaemia trait. All patients were anemic and during delivery mean Hb% were 8.42 g/dl, MCH 22.09 pg, MCV 73.56 fl, MCHC 29.86 g/dl and ferritin 241.51 ng/ ml. Third trimester USG exhibited 32% developed IUGR (Intrauterine growth restriction). 40% patients received blood transfusion after delivery. ? thalassaemia trait was identified in 20% babies at 6 month. Conclusion : Postpartum haemorrhage is a major complication of thalassaemia in pregnancy. After delivery a thorough neonatal check-up and haematological work-up is important for prevention of neonatal mortality and early detection of thalassaemia.
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An attempt was made to compare the analysis of investigative parameters to distinguish Amoebic Liver Abscess (ALA) from Pyogenic Liver Abscess (PLA). This study was carried out at Calcutta National Medical College & Hospital, Kolkata 700014. Patients were included with signs and symptoms suggestive of Liver Abscesses. The investigations of Serological, Hematological, Biochemical, Radiological and CT scan were done. Antimicrobial Therapy, Image Guided Percutaneous Aspirations/Drainage or Open surgical Drainage was performed and checked in follow-up visits up to 3 months. The highest incidences of Liver Abscess (53.3%) were encountered in alcoholic male. Fever and Abdominal Pain were common in both ALA and PLA. Hepatomegaly was significantly high (p<0.05) in PLA (64.2%) than ALA (37.5%), but jaundice was only noted in PLA (22.2%). E coli, K pneumonia and S aureus were confirmed in PLA. Alkaline Phosphatase was significantly high (p<0.05) in PLA. Right sided pleural effusion was noted in Chest X-ray of 50% case . USG studies measured 70% Solitary Abscesses with 5-10 cm in the Right Lobe. Partial resolution occurred in 28.6% of PLA and 31.2% of ALA. USG and Serological Tests are recommended and Conservative Management should be followed for ALA and invasive treatment for PLA patients
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Background: Trikatu, Sitopaladi, Hingavastaka, Avipattikara, Sringyadi and Talisadya are very popular Ayurvedic (churna) medicines practiced in India; however, unfortunately, they possess several qualitycontrol issues.Objective: The aim of this study was to find out a simple, accurate and sensitive HPTLC method for thedetection and quantification of marker molecule, piperine (alkaloid) on these Ayurvedic formulations forstandardization.Materials and methods: Methanolic extraction (reflux) was performed from the above six churnas as wellas three single ingredients Piper longum (pipul), Piper nigrum (marich) and Piper chaba (chai). HPTLC wasdone using piperine as a standard. The mobile phase was a mixture of toluene-ethyl acetate (7:3, v/v) anddetection at 342l.Results: The Rf was detected at 0.39. Piperine was quantified in all samples. P. nigrum showed higherpiperine than P. longum and P. chaba. The maximum piperine was noted in Hingavastaka churna andfollowed by Sringyadi churna, Sitopaladi churna, Talisadya churna, Trikatu churna and Avipattikara churna.Conclusion: This method can be successfully employed for standardization and quantitative analysis ofpiperine in Ayurvedic formulations (churnas) and also be helpful to clinicians and pharmacists to drawsignificant role of piperine present in all these samples.© 2017 Transdisciplinary University, Bangalore and World Ayurveda Foundation. Publishing Services byElsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
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LST-02 is a proprietary polyherbal formulation prepared by blending 50% standardized hydroethanolic extract of ten well-known herbs, namely Tinospora cordifolia, Phyllanthus amarus, Emblica officinalis, Terminalia chebula, Terminalia bellerica, Azadirachta indica, Adhatoda vasica, Picrorrhiza kurroa, Swertia chirata and Boerhaavia diffusa. The formulation was evaluated for hepatoprotective and antioxidant properties. The phenolic content and 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging abilities were evaluated to ascertain antioxidant property. In vitro hepatoprotective action was examined in carbon tetrachloride (CCl4) challenged isolated rat hepatocytes. Finally, LST-02 pretreatment was examined in D-galactosamine (GalN) induced (200 mg/kg; intraperitoneal) hepatitis in male Wistar rats, with silymarin 25 mg/kg as positive control. In vitro studies confirmed that LST-02 is rich in phenolic compounds. It could inhibited DPPH free radicals and exerted significant (p<0.05) protective activity against CCl4 induced injury in rat hepatocytes. Short-term pre-treatment with LST-02 (100 mg/kg and 200 mg/kg; oral) exhibited dose dependent protection against GalN induced hepatitis in rats (p<0.05). It significantly reduced GalN induced elevation of liver enzymes in serum and resisted oxidative stress by modulating catalase and reduced glutathione in hepatic parenchyma (p<0.05). The combination of herbal ingredients in LST-02 exerts hepatoprotective activity and a possible mechanism of this action is its antioxidant property.
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To study the effect of Body Revival (BR), a compound traditional Indian herbal medicine, on human platelet aggregation and isoproterenol (IS)-induced myocardial ischemia (MI) damage in male Wistar rats.
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Valeriana wallichii, an Indian medicinal plant, has been on trial for its role in stress disorders in hospital based clinical set-up. Hamilton's Brief Psychiatric Rating Scale (BPRS) was used and thorough clinical investigations were carried out to screen the subjects. Thirty-three subjects (20 male and 13 female; average age 34.2 years) were medicated with the plant extract in a fixed dose regime (500 mg/capsule, twice daily, p.o. after meal). They were thoroughly investigated clinically and using standard questionnaires based on different psychological rating scale at baseline (day 0), mid-term (day 30) and final (day 60). The observations exhibited that, V wallichii not only significantly (p < 0.001) attenuated stress and anxiety, but also significantly (p < 0.001) improved depression and also enhanced the willingness to adjustment. Nevertheless it did not alter memory, concentration or attention of the volunteers. The results suggest that V wallichii may be useful in the treatment of stress related disorders in human and may be a promising anti-stress agent in near future.
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Adolescent , Adult , Female , Humans , Male , Phytotherapy , Plant Preparations/pharmacology , Plant Roots , Stress, Psychological/drug therapy , ValerianABSTRACT
The immunomodulatory effects of Sonachandi Chyawanprash and Chyawanprash Plus--two herbal formulations have been evaluated. Both the drugs increased the macrophage activity and their number indicating enhancement of non-specific immune response and reduction of chances of infection. Besides that both Sonachandi Chyawanprash and Chyawanprash Plus efficiently protected Cyclosporine A induced immunosuppression suggesting the immunoprotective role of the aforesaid herbal formulations.